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Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb

Ogunlana, Olubanke Olujoke and He, Wen-Jun and Fan, Jun-Ting and Zeng, Guang-Zhi and JI, Chang-Jiu and Zheng, Yu Quing and Olagunju , J. A and Akindahunsi, A. A. and Tan, Ning-Hua (2015) Cytotoxic flavonoids from the young twigs and leaves of Caesalpinia bonduc (Linn) Roxb. J. Pharm. Sci., 28 (6). pp. 2191-2198.

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The extraction, fractionation and recognition of flavonoids from the ethanolic extract of young twigs and leaves of C. bonduc were carried out. In addition, cytotoxic study of the flavonoids on two cancer cell lines, BGC-823 and HeLa was carried our using sulphorhodamine B assay. Seven flavonoids, six of which are being reported for the first time in this plant, were isolated. Their structures were identified by MS and NMR spectroscopic methods. Petroleum ether, ethyl acetate and water fractions exhibited moderate cytotoxic activity against HeLa cells. Five compounds showed cytotoxic activity against HeLa cell in comparison with Paclitaxel, while only one compound showed a good degree of cytotoxic activity against BGC-823 cell in comparison to Paclitaxel. The results obtained showed a structure - activity relationship.

Item Type: Article
Uncontrolled Keywords: Caesalpinia bonduc; flavonoids; cytotoxic activity.
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 18 Dec 2015 13:14
Last Modified: 02 Sep 2016 12:31

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