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In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum

Isewon, Itunuoluwa and Oyelade, O. J. and Brors, B. and Adebiyi, Ezekiel (2015) In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum. Libertas Academica. 231- 238.

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The Maurer’s clefts (MCs) are very important for the survival of Plasmodium falciparum within an infected cell as they are induced by the parasite itself in the erythrocyte for protein trafficking. The MCs form an interesting part of the parasite’s biology as they shed more light on how the parasite remodels the erythrocyte leading to host pathogenesis and death. Here, we predicted and analyzed the genetic regulatory network of genes identified to belong to the MCs using regularized graphical Gaussian model. Our network shows four major activators, their corresponding target genes, and predicted binding sites. One of these master activators is the serine repeat antigen 5 (SERA5), predominantly expressed among the SERA multigene family of P. falciparum, which is one of the blood-stage malaria vaccine candidates. Our results provide more details about functional interactions and the regulation of the genes in the MCs’ pathway of P. falciparum.

Item Type: Article
Uncontrolled Keywords: Maurer’s cleft, gene regulatory network, Plasmodium falciparum, graphical Gaussian model
Subjects: Q Science > Q Science (General)
Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions: Faculty of Engineering, Science and Mathematics > School of Electronics and Computer Science
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 14 Jan 2016 12:18
Last Modified: 14 Jan 2016 12:18

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