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Phytochemical, Cytotoxicity and Antioxidant Activities of Five Anti-malaria Plants

Omonhinmin, Conrad A. and Dike, IP and Rotimi, SO (2015) Phytochemical, Cytotoxicity and Antioxidant Activities of Five Anti-malaria Plants. Research Journal of Medicinal Plant, 9. pp. 81-89.

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Abstract

The study investigated the phytochemical, cytotoxicity and antioxidant properties of Allamanda cathartica (AC), Bixa orellana (BO), Cymbopogon citratus (CC), Ficus exasperata (FE) and Momordica charantia (MC) used traditionally for the anti-malarial preparations “Agbo” in Nigeria. Phytochemical screening of the plants showed the presence of flavonoids, terpenoids, phenolics, cardiac glycosides and reducing sugars. Free radical scavenging activity of the plants with 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) recorded significant IC50 values for the inhibition of DPPH by ethanolic leaves extracts of AC (0.46), BO (0.45), CC (1.35) and FE (0.86), respectively and Vit. E (control), recorded higher activity at 0.5 mg mLG1 with an IC50 of 0.25 μg mLG1 . BO leaf extracts recorded the most potent effect (0.45) at low concentration of 0.5 mg mLG1 . The free radical scavenging activities of these plants doubtlessly contribute to their use in indigenous malaria therapy and may qualify them for anti-malarial drug screening.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Solomon Rotimi
Date Deposited: 16 Feb 2016 15:40
Last Modified: 29 Feb 2016 10:07
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/5905

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