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Anti-Tubercular Compounds from Spondias Mombin

OLUGBUYIRO, J.A.O (2013) Anti-Tubercular Compounds from Spondias Mombin. International Journal of Pure and Applied Sciences and Technology, 19 (2). pp. 76-87. ISSN 2229 - 6107

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Spondias mombin is a widely cultivated edible plant used in folkloric medicine for the treatment of severe cough and other respiratory disorders. This study evaluated the anti tubercular property of the stem of S. mombin against Mycobacterium tuberculosis (H37Rv and EJA-2011) using agar proportion assay on Lowenstein-Jensen medium. Four new compounds were isolated from the stem of Spondias mombin and they were identified as mombinrin (1), mombincone (2), mombinoate (3) and mombinol (4) respectively. Compound 1 is a coumarin, 2-4 are flavonoids. At 40 µg/mL concentration, the four compounds exhibited significant inhibitions (p < 0.05) against M. tuberculosis. At a lower dose of 25 µg/mL, compounds 1 and 3 exhibited significant antimycobacterial inhibitions (96.0 % and 97.6 % respectively; p < 0.05) while compounds 2 and 4 showed moderate inhibitions (85.0 % and 88.0 % respectively). The findings show that Spondias mombin accumulates antimycobacterial compounds that may serve as an important potential source for anti-tubercular agents.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Date Deposited: 25 Feb 2016 07:58
Last Modified: 25 Feb 2016 07:58

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