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Modeling of the Glycolysis Pathway in Plasmodium falciparum using Petri Nets

Oyelade, O. J. and Isewon, Itunuoluwa and Rotimi, Solomon and Okunoren, Ifeoluwa (2016) Modeling of the Glycolysis Pathway in Plasmodium falciparum using Petri Nets. Libertas AcademicaBioinformatics and Biology Insights.

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Abstract

Malaria is one of the deadly diseases, which affects a large number of the world’s population. The Plasmodium falciparum parasite during erythrocyte stages produces its energy mainly through anaerobic glycolysis, with pyruvate being converted into lactate. The glycolysis metabolism in P. falci-parum is one of the important metabolic pathways of the parasite because the parasite is entirely dependent on it for energy. Also, several glycolytic enzymes have been proposed as drug targets. Petri nets (PNs) have been recognized as one of the important models for representing biological pathways. In this work, we built a qualitative PN model for the glycolysis pathway in P. falciparum and analyzed the model for its structural and quantitative properties using PN theory. From PlasmoCyc files, a total of 11 reactions were extracted; 6 of these were reversible and 5 were irreversible. These reactions were catalyzed by a total number of 13 enzymes. We extracted some of the essential reactions in the pathway using PN model, which are the possible drug targets without which the pathway cannot function. This model also helps to improve the understanding of the biological processes within this pathway.

Item Type: Article
Uncontrolled Keywords: glycolysis, petri nets, plasmodium falciparum, PlasmoCyc
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Engineering, Science and Mathematics > School of Electronics and Computer Science
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 10 Aug 2016 12:39
Last Modified: 10 Aug 2016 12:39
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/6819

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