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Preparation, Release Pattern And Antibacterial Activities Of Chitosan-Silver Nanocomposite Film

SONDE, O. IDOWU and OGUNGBESAN, SHEPRAH O. and OLOYEDE, OLOYEDE, A.R and IDOWU, MOPELOLA A. and AFOLABI, T.ADENIYI and DARE, ENOCH O. (2016) Preparation, Release Pattern And Antibacterial Activities Of Chitosan-Silver Nanocomposite Film. In: Covenant University Chemistry Conference 2016.

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The present study examined the preparation of chitosan-silver nanocomposite film as carriers for silver release pattern. Chitosan, a biopolymer having immense structural possibilities for chemical and mechanical modifications to generate novel properties, functions and applications. Chitosan – silver nanocomposite has been synthesized by simple chemical reduction method, which is a simple and an inexpensive method. The chitosan-silver (crosslinked) nanocomposite film was characterized in terms of their surface plasmon resonance and crystalline structure by using UV-Visible spectroscopy, X-ray diffraction, Fourier transform infrared and Scanning electron microscope. Swelling and release studies were carried out on the nanocomposite film. Antibacterial activities of chitosan-silver nanocomposite film were investigated on human pathogens: Staphylococcus aureus, Shigella dysenteriae, Escherichia coli, Salmonella typhii and Klebsiella pneumonia using agar well diffusion method. Chitosan-silver (crosslinked) demonstrated a slower release pattern relative to silver-chitosan (uncrosslinked); both became dislodged and completely released at 120 minutes and 90 minutes respectively. The results of the antibacterial activities revealed that the cross-linked nanocomposite film has higher antibacterial properties than the close component. This study provides novel nanocomposite film potentially useful for drug delivery.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Biopolymer, Carrier, Chitosan, Nanocomposite, Antibacterial
Subjects: Q Science > QD Chemistry
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 11 Aug 2016 14:43
Last Modified: 11 Aug 2016 14:43

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