SONDE, O. IDOWU and OGUNGBESAN, SHEPRAH O. and OLOYEDE, OLOYEDE, A.R and IDOWU, MOPELOLA A. and AFOLABI, T.ADENIYI and DARE, ENOCH O. (2016) Preparation, Release Pattern And Antibacterial Activities Of Chitosan-Silver Nanocomposite Film. In: Covenant University Chemistry Conference 2016.
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Abstract
The present study examined the preparation of chitosan-silver nanocomposite film as carriers for silver release pattern. Chitosan, a biopolymer having immense structural possibilities for chemical and mechanical modifications to generate novel properties, functions and applications. Chitosan – silver nanocomposite has been synthesized by simple chemical reduction method, which is a simple and an inexpensive method. The chitosan-silver (crosslinked) nanocomposite film was characterized in terms of their surface plasmon resonance and crystalline structure by using UV-Visible spectroscopy, X-ray diffraction, Fourier transform infrared and Scanning electron microscope. Swelling and release studies were carried out on the nanocomposite film. Antibacterial activities of chitosan-silver nanocomposite film were investigated on human pathogens: Staphylococcus aureus, Shigella dysenteriae, Escherichia coli, Salmonella typhii and Klebsiella pneumonia using agar well diffusion method. Chitosan-silver (crosslinked) demonstrated a slower release pattern relative to silver-chitosan (uncrosslinked); both became dislodged and completely released at 120 minutes and 90 minutes respectively. The results of the antibacterial activities revealed that the cross-linked nanocomposite film has higher antibacterial properties than the close component. This study provides novel nanocomposite film potentially useful for drug delivery.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Uncontrolled Keywords: | Biopolymer, Carrier, Chitosan, Nanocomposite, Antibacterial |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | UNSPECIFIED |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 11 Aug 2016 14:43 |
| Last Modified: | 11 Aug 2016 14:43 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/6828 |
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