He, Wen-Jun and Chu, Hong-Biao and Zhang, Yu-Mei and Han, Hong-Jin and Yan, He and Zeng, Guang-Zhi and Fu, Zhao-Hui and Ogunlana, Olubanke Olujoke and Tan, Ning-Hua (2011) Antimicrobial, cytotoxic lignans and terpenoids from the twigs of Pseudolarix kaempferi. Planta medica , 77 (17). pp. 1924-1931.
Full text not available from this repository.Abstract
Seven new compounds, including four lignans, (+)-(8S,8′S)-9,9′-dibenzoylsecoisolariciresinol (1), (+)-(8S*,8′R*)-4,4′-dimethyloxomatairesinol (2), (+)-(7S*,8R*,8′R*,9′S*)-9′-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, pseudolarkaemin B (5), an ent-beyerene glycoside, pseudolarkaemin C (6), and a triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (8–32) were isolated from the twigs of Pseudolarix kaempferi. Their structures were elucidated mainly by the analysis of their NMR and MS data. Pseudolarolide C acid (24) was isolated for the first time as a natural product. All compounds were evaluated for antimicrobial activity against Candida albicans and Staphylococcus aureus, and cytotoxic activity against K562, HT-29, B16, BGC-823, BEL-7402, SGC-7901, U251, and A549 cancer cell lines were assayed. Results indicated that the new compounds 3, 7, and some known compounds showed antimicrobial and cytotoxic activities.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Dr. Olubanke Olujoke Ogunlana |
| Date Deposited: | 02 Sep 2016 12:18 |
| Last Modified: | 06 Sep 2017 14:52 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/6979 |
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