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The interplay of post-translational modification and gene therapy

Osamor, V. C. and Chinedu, S. N. and Azuh, Dominic E. and Iweala, E. E. J. and Ogunlana, Olubanke Olujoke (2016) The interplay of post-translational modification and gene therapy. Dove Pressmmons . pp. 861-871.

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Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on whether histone marks are read, added, or removed, respectively, from a specific amino acid. Transcription is controlled by dynamic epigenetic marks with serious health implications in certain complex diseases, whose understanding may be useful in gene therapy. This work highlights traditional and current advances in post-translational modifications with relevance to gene therapy delivery. We report that enhanced understanding of epigenetic machinery provides clues to functional implication of certain genes/gene products and may facilitate transition toward revision of our clinical treatment procedure with effective fortification of gene therapy delivery

Item Type: Article
Uncontrolled Keywords: post-translational modification, gene therapy, epigenetics, histone, methylation
Subjects: Q Science > Q Science (General)
Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions: Faculty of Engineering, Science and Mathematics > School of Electronics and Computer Science
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 09 Jan 2017 15:35
Last Modified: 09 Jan 2017 15:35

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