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Synthesis, Characterisation and pH-Responsive Controlled Release Studies of 5- Fluorouracil Drug from Silica CoatedLao.1Sro.3Mn03Magnetic Nanoparticles

Ehi-Eromosele, C. O. and Ita, B. I. (2016) Synthesis, Characterisation and pH-Responsive Controlled Release Studies of 5- Fluorouracil Drug from Silica CoatedLao.1Sro.3Mn03Magnetic Nanoparticles. In: International Confernece, Theme: Chemical Sciences Solutions to Global challenges, 15th - 17th, February, 2016, Julius Berger Lecture Theatre, University of Lagos, ARoRa, Lagos.

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Abstract

One of the drawbacks of some drug delivery system (DDS) is their inability to release their payloads after reaching the desired site of action. Hence, many DDSs are being evaluated that are able to release their payloads upon action of an external stimulus. La0.7SrO.JMn03 MNPs were synthesized by solution combustion synthesis and the optimised MNPs were coated with silica. The synthesized MNPs were characterised by X-ray diffraction (XRD), thermogravimetry-differential thermal analysis (TG-DTA), field emission scanning electron microscope (FE-SEM), energy dispersive absorption spectroscopy (EDAX), fourier transform infra-red spectroscopy (FTIR), vibrating scanning magnetometer (VSM), zeta potential measurements and ultraviolet-visible spectroscopy (UV-Vis). The anticancer drug delivery capability of La0.7SrO.JMn03 MNPs was carried out. Silica coatings with were utilised for the loading of 5-Fluoro uracil (5-FU)- a well-known anti-cancer drug. The silica surface was functionalised with amino propyl (LSMO-Si02-NH2) to achieve charge reversal of the designed system from negative to positive as pH varied from 7.4 to 5 which was used for the effective release of the cargo at endosomal pH 5. The high 5-FU drug loading and its pH-sensitive release from LSMO-Si02-NH2 suggest that it is a promising material for targeted drug delivery applications

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: Lao.1Sro.JMn03; Magnetic nanoparticles; Silica; cancer therapy; combustion synthesis; 5-Fluoro uracil
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 18 Jan 2017 15:39
Last Modified: 18 Jan 2017 15:39
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/7575

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