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AN EVALUATION OF SORGHUM BICOLOR (Linn.) MOENCH LEAF SHEATH EXTRACT IN HIGH FAT DIET-INDUCED OBESE RATS

Ugbaja, RN and Owoeye, F. D. and Akinloye, O. A. and Dedeke, G. A. (2015) AN EVALUATION OF SORGHUM BICOLOR (Linn.) MOENCH LEAF SHEATH EXTRACT IN HIGH FAT DIET-INDUCED OBESE RATS. Ife Journal of Science, 17 (3). pp. 667-683.

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Abstract

Obesity, resulting from energy imbalance caused by an increased ratio of caloric intake to energy expenditure is a global health problem. This study investigated the effects of Sorghum bicolor leaf extracts (SBE) on blood lipid levels in high fat diet-induced obese rats. Sorghum bicolor leaf was extracted with 70% ethanol using Soxhlet extractor. Male Wistar rats (n=36) divided into six groups: (A) normal control, (B) obese control (High Fat Diet – HFD), (C) HFD+150 mg/kg body weight SBE (first treatment), (D) HFD+300 mg/kg body weight SBE (second treatment), (E) HFD+600 mg/kg body weight SBE (third treatment) and (F) HFD+ 1200 mg/kg body weight SBE (fourth treatment) were used. The SBE was administered orally to the animals daily for 28 days. Body weight was taken weekly and Lee index was calculated alongside. Plasma, erythrocytes and lipoproteins' lipid profiles were determined using spectrophotometric methods. Results from the study revealed that generally, SBE significantly reduced (p<0.05) the levels of cholesterol, phospholipids, triacylglycerol by varying levels, in the various blood compartments of the obese animals. It was observed that SBE caused a significant (p<0.05) decrease in plasma cholesterol level of the fourth treatment group. Also, SBE significantly (p<0.05) reduced the elevated atherogenic and coronary risk indices by 50%. This study suggests that SBE might be useful in the management of obesity and its co-morbid conditions.

Item Type: Article
Uncontrolled Keywords: Obesity, Sorghum bicolor, management, plasma, lipoproteins
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 14 Feb 2017 11:38
Last Modified: 14 Feb 2017 11:38
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/7782

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