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Evaluation of Rapid Methods in Malaria Diagnosis from Persons attending Primary Health Facilities, Ogun State, Nigeria

Adekunle, NO and Sam-Wobo, S. O. and Dedeke, G. A. and Ojo, DA and Abimbola, WA and Adeleke, MA and Surakat, OA (2014) Evaluation of Rapid Methods in Malaria Diagnosis from Persons attending Primary Health Facilities, Ogun State, Nigeria. Nigerian Journal of Parasitology, 35 (1-2). pp. 19-25. ISSN 1117 4145

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Malaria in Nigeria is treated blindly in most cases and where diagnostic measures exist, efficacies of several are still in doubt. This study evaluated performance of microscopy and rapid (RDT) methods in confirming prevalence of malaria parasites (MP),parasite species and percent parasitized red blood cells in 384 persons systematically selected from seven primary healthcare facilities in Ogun State, Nigeria from October to December 2012. Giemsa thin and thick film techniques and RDT (SD Bioline Ag P.f/Pan kit) were employed on the blood samples. Data were analysed using SPSS version 16. Demographic results showed that females were 61% and males 39%,but of varying age groups. Seventy-one percent of the blood samples were positive for MP by microscopic blood films, and only 24% samples were positive by RDT. Paired sample T-test showed a significant difference (P=0.000)between microscopy and RDT methods. Of the 273 positive blood samples,95.6%were P. falciparum,3.3% were P. malariae, 0.7% was P. ovale and P. vivax (0.4%). For RDT, P. falciparum was 74% while mixed infections were 26%. Prevalence in risk groups 0–10 and 11–20 age groups was observed to be higher with significant differences (p=0.011, p=0.023) for both microscopy and RDT respectively. RDT sensitivity and specificity were 23.4% and 74.7% compared to microscopy. Positive Predictive Value and Negative Predictive Value were 69.6% and 28.4%. The efficiency of the RDT was 38.3%. The low sensitivity of RDT observed means that malaria diagnosis by microscopy method remains the gold standard

Item Type: Article
Uncontrolled Keywords: Rapid Diagnostic, microscopy, malaria parasites, health facilities, Ogun State
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 20 Feb 2017 12:22
Last Modified: 20 Feb 2017 12:22

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