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A new chromene isolated from Ageratum conyzoides.

Adebayo, H. A. and Jig, Cj and Zhang, Yu-Mei and He, Wen-Jun and Zeng, Guang-Zhi and Han, Hong Jin and Xu, Jun-Ju and Akindahunsi, A. A. and Tana, NH (2011) A new chromene isolated from Ageratum conyzoides. Search worldwide, life-sciences literature, 6 (9). pp. 1263-1265.

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Abstract

From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3',5'-Tri-O-methyltricetin (7), precocene II (9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 microM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61 microM; the others showed no significant cytotoxic activity on the cell lines tested.

Item Type: Article
Subjects: Q Science > QH Natural history
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 16 Mar 2017 09:27
Last Modified: 16 Mar 2017 09:27
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/7941

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