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A comparative assessment of toxic effects of dimethylnitrosamine in six different species

Maduagwu, E. N. and Bassir, Olumbe (1980) A comparative assessment of toxic effects of dimethylnitrosamine in six different species. Toxicology and Applied Pharmacology, 53 (2). pp. 211-219.

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The hepatotoxicity which usually accompanies the oral administration of dimethylnitrosamine (DMN) to laboratory animals was studied in male rats, guinea pigs, cats, lizards, ducks, and monkeys. A single dosage of 50 mg/kg, which is necrotizing to rat liver, in most cases produced within 30 hr more acute liver damage in cats than in guinea pigs, rats, or monkeys, in that order of susceptibility, but was not toxic to lizards or ducks. DMN (5 mg/kg), given daily, induced the same degree of liver damage in guinea pigs and rats as did a single dose of the same compound. However, in cats and monkeys the effect of a single dose of 50 mg/kg was less severe than that obtained after the administration of 5 mg/kg over a period of 5–11 days. DMN (1 mg/kg), administered daily over a period of 30 days, was particularly harmful to cats and lizards. Clinicopathologic signs of overt toxicity were also monitored. Our results would support the view that species differences and dosage rates are both critical factors determining the different susceptibilities of various animals to nitrosamine toxicity.

Item Type: Article
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 21 Mar 2017 15:39
Last Modified: 21 Mar 2017 15:39

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