Adebayo, H. A. and Abolaji, A. O. and Opata, T. K. and Adegbenro, I. K.
(2010)
Effects of ethanolic leaf extract of Chrysophyllum albidum G. on biochemical and haematological parameters of albino Wistar rats.
African Journal of Biotechnology, 9 (14).
pp. 2145-2150.
ISSN 1684-5315
Abstract
The effect of oral administration of the leaf extract of Chrysophyllum albidum G. on biochemical and
haematological parameters were investigated in albino rats for 16 days. The extract did not show any
significant effect (p > 0.05) on the plasma concentrations of total bilirubin, albumin and alkaline
phosphatase (ALP) as well as the packed cell volume (PCV), haemoglobin (Hb), red blood cell (RBC),
reticulocytes, neutrophils, lymphocytes, eosinophils, basophils, mean corpuscular haemoglobin
concentration (MCHC) and mean corpuscular haemoglobin (MCH). The concentration of the platelets
was significantly decreased (p < 0.05) at 1000 mg/kg body weight, while white blood cell (WBC) was
significantly increased at 500 mg/kg body weight. The doses significantly reduced (p < 0.05) plasma
levels of AST, ALT, total protein, glucose and creatinine while urea was significantly increased. While
the extract significantly increased the lung, brain and liver-body weights, the kidney, heart, testis,
spleen and epididymis-body weights were not significantly affected. The result suggests that the leaf
extract of C. albidum contains antiplatelet and hypoglycemic properties and exhibited selective organ
toxicity to the rats.
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