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Comparative in vitro metabolisms of dimethylnitrosamine in animals of six different species.

Maduagwu, E. N. and Bassir, Olumbe (1980) Comparative in vitro metabolisms of dimethylnitrosamine in animals of six different species. Journal of Environmental Pathology and Toxicology, 4 (5-6). pp. 229-235.

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Abstract

The in vitro metabolisms of dimethylnitrosamine (DMN) by liver slices and microsomal + soluble fractions, respectively, were studied in the rat, guinea pig, cat, duck, lizard and monkey using disappearance of DMN and the formation of formaldehyde, in situ, as indices of the decomposition of the compound. All the animal species investigated metabolised DMN, and the rate of metabolism of the compound was highest in media containing cat tissue and lowest in that containing duck tissue. The rat and guinea pig however appeared to metabolise DMN at comparable rates. Our results would suggest that DMN demethylase activity in the liver is a linear function of time. These results are discussed in relation to the toxicity of possible DMN metabolites

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 23 Mar 2017 15:32
Last Modified: 23 Mar 2017 15:32
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/8015

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