Alaneme, F. O. and Maduagwu, E. N. (2004) Pharmacokineticosf biliary excretion of N-nitrosodimethylaminein ratsf ed dietsc ontainingle velso f protein. MALAWI MED. JOURNAL, 16 (1). pp. 6-8.
![[img]](http://eprints.covenantuniversity.edu.ng/style/images/fileicons/application_pdf.png) |
PDF
Download (4MB) |
Abstract
Albino Wistar rats (Rattus nomegius) fed semi-purified diets ssnf qini n g 3.5 Vo, 8 Vo, 27 Vo, and 64 Vo casein, respectively, as the protein source, were poisoned with an intraperitoneal dose of 20mg N-nitrosodimethylamine (NDMA/kg, following cannulation of the bile duct, in vitro, under urethane anaesthesia Bile exudates was collected at designated time intervals and analysed for unchangetl NDMA using thin layer chromatography and gas liquid chromatography methods. Rats on 64Vo htgh protein diet (HpD) were the highest excretors of NDMA, followed by rats on the 3.SVo kwashiorkorigenic diet (KWD), 8Vo low protein diet (LpD) and,27Von ormal protein diet (NDP) as the leaste xcretors,i n that order. The corresponding values for culmulative excretionso f NDMA were4 .38Vo2, .74Vo,2.96Vaon d4. .ll7o, and, for elimination rate contents they were 54.05Kh", 23.01Kh-', 23.76Kh" and 48.88Kh'', while the respective elimination half-life values were 0.013h, 0.031h, 0.029h and 0.014h. The toxicological and pharmacological implication of the pharmacokinetic findings are discussed
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Patricia Nwokealisi |
| Date Deposited: | 27 Mar 2017 14:50 |
| Last Modified: | 27 Mar 2017 14:50 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/8036 |
Actions (login required)
 |
View Item |
