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Haematopoietic induction and hepatic protective roles of Hepacare® in CCl4-induced hepatic damaged rats

Adebayo, H. A. and Yakubu, Omolara Faith and Adegbite, Oluwatobi Samuel and Okubena, O. (2017) Haematopoietic induction and hepatic protective roles of Hepacare® in CCl4-induced hepatic damaged rats. ORIGINAL ARTICLE.

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Abstract

Herbal formulations are plant parts used as raw materials for self-administered pharmaceutical remedies, and many of them are being sold without any scientific validation for their potency and efficacy. This research work was aimed at evaluating the haematopoietic, biochemical, and histologi- cal effects of Hepacare®, a popularly sold herbal formulation in Nigeria against carbon tetrachloride (CCl4)-mediated liver damage in rats. Haematological analysis showed significant reduction (p < 0.05) in haemoglobin, red blood cell, packed cell volume, and platelet counts in CCl4-treated group when compared with the untreated group. These parameters were however reversed across the groups treated with the herbal formulation. Levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin were significantly (p < 0.05) reduced after treatment of rats with the formulation which were previously elevated (p < 0.05) in the CCl4-treated group when compared with the untreated group. The CCl4-treated group exhibited significantly different activities in liver SOD and GSH enzymes. The level of MDAwas lowered in the liver tissue samples of treated ratswhen compared with the CCl4-exposed untreated rats. The groups treated with the formulation showed signs of protection against this toxicant as evidenced by the absence of necrosis. Hepacare® showed reversal effects on the previously increased haematological parameters and damaged liver tissues with a potential to ameliorate oxidative stress in hepatic dysfunction

Item Type: Article
Uncontrolled Keywords: Hepacare® . Carbon tetrachloride . Haematologic . Liver injury . Hepaticmarker enzymes . Antioxidant markers . Histological examination
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 29 Aug 2017 13:25
Last Modified: 29 Aug 2017 13:25
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/8971

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