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Heterogeneous Catalytic Efficiency of Silica Sulfuric Acid towards the Synthesis of Substituted Pyrimidin-2 (1H)-One Derivatives

Ajani, Olayinka O. and Owoeye, T. F. and Olanrewaju, I. O. and Adedapo, Adebusayo E. and Ajanaku , C. O. (2016) Heterogeneous Catalytic Efficiency of Silica Sulfuric Acid towards the Synthesis of Substituted Pyrimidin-2 (1H)-One Derivatives. In: 39th Annual International Conference Workshop and Exhibition, 18th -23rd September 2016, Law Faculty, Rivers State University of Science and Technology, Port Harcourt, Rivers State, Nigeria.

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Abstract

Pyrimidine template is a highly privileged motif for the development of molecules of biological and pharmaceutical interest due to its prebiotic nature to life. This present study deals with the synthesis of pyrimidin- 2(1H)-one derivative from chalcones by the action of silica supported sulfuric acid (SSA) or conventional refluxed in concentrated hydrochloric acid. The chemical structures were confirmed by analytical data and spectroscopic means such as UV, IR, mass spectra, 1H and 13C NMR. SSA was found to be efficient method for the quantitative transformation to pyrimidine frame work. It can be re-used after simple washing with chloroform thereby rendering this procedure more economical.

Item Type: Conference or Workshop Item (Paper)
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mr Adewole Adewumi
Date Deposited: 02 Sep 2017 00:30
Last Modified: 02 Sep 2017 00:30
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/9076

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