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Evaluation of Biochemical Toxicity and Antioxidant Properties of Pioglitazone on Albino Wistar Rats

Ogunlana, Olubanke Olujoke and Ogunlana, Oluseyi Ebenezer and Ugochukwu, Stanley K and Ashano, Efejiro (2017) Evaluation of Biochemical Toxicity and Antioxidant Properties of Pioglitazone on Albino Wistar Rats. Journal of Medical Sciences, 17 (1). pp. 10-16. ISSN 1682-4474

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Abstract

Pioglitazone is one of the thiazolidinedione anti-diabetic drugs which have been used for the treatment of non-insulin dependent diabetes mellitus. This study aims at investigating the biochemical effects and safety of pioglitazone (PIO) at various concentrations in female Wistar rats. A total of 28 rats were randomly divided into four groups of seven animals each. Groups 1-4 were given 0.5 mL kgG1 b.wt., dayG1 of distilled water as normal control; 15, 30 and 45 mg kgG1 b.wt., dayG1 of PIO, respectively as treatment groups 2, 3 and 4, respectively for 28 days. Using standard biochemical kits and reported chemical procedures, plasma biochemical parameter and organ lipid peroxidation effects were determined in all the groups. There was significant increase (p<0.05) in plasma total protein concentration of group 3 and 4 in comparison with control. There was also significant (p<0.05) reduction in total and LDL cholesterols in PIO-treated groups and concentration of TBARS was reduced in the liver and heart of PIO-treated groups in comparison with normal control. There was no significant alteration in the concentrations and activities of liver and kidney function markers of PIO treated groups in comparison with normal control groups. Pioglitazone at highest concentration of 45 mg kgG1 b.wt., for the duration of 28 days did not elicit any measurable biochemical toxicity on non-diabetic rat model

Item Type: Article
Uncontrolled Keywords: Pioglitazone, hepatic biochemical markers, renal biochemical markers, lipid peroxidation
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs. Julie Ilogho
Date Deposited: 05 Sep 2017 12:05
Last Modified: 05 Sep 2017 12:05
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/9105

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