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Estimating the prevalence,hospitalisation and mortality from type 2 diabetes mellitus in Nigeria: a systematic review and meta-analysis

Adeloye, Davies and lge, Janet O and Aderemi, Adewale Victor and Adeleye, Ngozi and Amoo, Emmanuel O. and Auta, Asa and Oni, Gbolahan (2017) Estimating the prevalence,hospitalisation and mortality from type 2 diabetes mellitus in Nigeria: a systematic review and meta-analysis. BMJ Open.

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Abstract

Background There is not yet a comprehensive evidencebased epidemiological report on type 2 diabetes mellitus (T2DM) in Nigeria. We aimed to estimate country-wide and zonal prevalence, hospitalisation and mortality rates of T2DM in Nigeria. Methods We searched MEDLINE, EMBASE, Global Health, Africa Journals Online (AJOL) and Google Scholar for population and hospital-based studies on T2DM in Nigeria. We conducted a random-effects meta-analysis on extracted crude estimates, and applied a meta-regression epidemiological model, using the United Nations demographics for Nigeria in 1990 and 2015 to determine estimates of diabetes in Nigeria for the two years. Results 42 studies, with a total population of 91 320, met our selection criteria. Most of the studies selected were of medium quality (90.5%). The age-adjusted prevalence rates ofT2DM in Nigeria among persons aged 2D-79 years increased from 2.0% (95% Cl1.9% to 2.1 %) in 1990 to 5. 7% (95% Cl 5.5% to 5.8%) in 2015, accounting for over 87 4 000 and 4. 7 million cases, respectively. The pooled prevalence rate of impaired glucose tolerance was 10.0% (95% Cl 4.5% to 15.6%), while impaired fasting glucose was 5.8% (95% Cl3.8% to 7.8%). Hospital admission rate for T2DM was 222.6 (95% Cl133.1 to 312.1) per 100 000 population with hyperglycaemic emergencies, diabetic foot and cardiovascular diseases being most common complications. The overall mortality rate was 30.2 (95% Cl 14.6 to 45.8) per 100 000 population, with a case fatality rate of 22.0% (95% Cl 8.0% to 36.0%). Conclusion Our findings suggest an increasing burden of T2DM in Nigeria with many persons currently undiagnosed, and few known cases on treatment.

Item Type: Article
Subjects: H Social Sciences > H Social Sciences (General)
H Social Sciences > HA Statistics
Divisions: Faculty of Law, Arts and Social Sciences > School of Social Sciences
Depositing User: Mrs Hannah Akinwumi
Date Deposited: 06 Nov 2017 11:16
Last Modified: 06 Nov 2017 11:16
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/9607

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