SALAKO, ABIODUN EVELYN and Covenant University, Theses (2018) EFFECT OF Tetracarpidium conophorum EXTRACT ON TESTOSTERONE-INDUCED BENIGN PROSTATIC HYPERPLASIA IN MALE WISTAR RATS. Masters thesis, COVENANT UNIVERSITY.
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Abstract
Benign prostatic hyperplasia (BPH) is the enlargement of the prostate, a walnut-sized gland located just below the bladder. Currently, two main treatment options are available for BPH patients: 5-alpha reductase inhibitors (finasteride) and alpha-1-adrenergic receptor antagonists. However, these drugs can produce undesirable side effects. In this study, the levels of antioxidant (superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH)), prostate specific antigen (PSA), relative prostate weight and phytochemicals were investigated in Tetracarpidium conophorum leaf extract on the development of BPH in male Wistar rat. Thirty (30) animals were randomly divided into six groups of five animals each. All treatments were administered to animals concurrently for four (4) weeks. Group A (normal control) received olive oil subcutaneously and other groups (B, C, D, E and F) received subcutaneous injection of testosterone propionate. Tetracarpidium conophorum (100, 200 and 400 mg/kg body weight) was administered by oral gavage daily to Groups C, D and E respectively while Group F received finasteride. From the phytochemical screening result obtained, saponins, phenols, tannin, flavonoid, steroid, glycoside, terpenoids and alkaloids were present. Animals in group E showed significant decrease (p<0.05) in relative prostate weight (10×10-4±29×10-5g) and serum PSA level (91.83±5.78pg/ml) when compared to relative prostate weight (17×10-4±84×10-6g) and serum PSA level (174.8±3.13pg/ml) of group B. However, a significant increase (p<0.05) in group E was observed in the levels of CAT (31.74±1.43U/mg protein), SOD (52.85±1.23U/mg protein) and GSH (16.50±0.28U/ml) when compared to levels of CAT (11.04±0.44U/mg protein), SOD (33.36±1.27U/mg protein) and GSH (7.28±0.27U/mg protein) of group B. It may therefore be concluded that oral administration of Tetracarpidium conophorum at 400mg/kg can prevent the development of BPH induced by testosterone.
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 08 Jul 2020 12:32 |
| Last Modified: | 08 Jul 2020 12:32 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/13467 |
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