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Amoxillin-and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues

Rotimi, S.O. and Ojo, D.A. and Talabi, O.A. and Ugbaja, R.N. and Balogun, E.A. and Ademuyiwa, O. (2015) Amoxillin-and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues. Lipids in Health and Disease, 14 (1).

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Background: To investigate whether amoxillin and pefloxacin perturb lipid metabolism. Methods: Rats were treated with therapeutic doses of each antibiotic for 5 and 10 days respectively. Twenty four hours after the last antibiotic treatment and 5 days after antibiotic withdrawal, blood and other tissues (liver, kidney, brain, heart and spleen) were removed from the animals after an overnight fast and analysed for their lipid contents. Results: Both antibiotics produced various degrees of compartment-specific dyslipidemia in the animals. While plasma and erythrocyte dyslipidemia was characterised by up-regulation of the concentrations of the major lipids (cholesterol, triglycerides, phospholipids and free fatty acids), hepatic and renal dyslipidemia was characterised by cholesterogenesis and phospholipidosis. Splenic dyslipidemia was characterised by cholesterogenesis and decreased phospholipid levels. Cardiac and brain cholesterol contents were not affected by the antibiotics. A transient phospholipidosis was observed in the brain whereas cardiac phospholipids decreased significantly. Lipoprotein abnormalities were reflected as down-regulation of HDL cholesterol. Furthermore, the two antibiotics increased the activity of hepatic HMG-CoA reductase. Although erythrocyte phospholipidosis was resolved 5 days after withdrawing the antibiotics, dyslipidemia observed in other compartments was still not reversible. Conclusion: Our findings suggest that induction of cholesterogenesis and phospholipidosis might represent additional adverse effects of amoxillin and pefloxacin. © 2015 Rotimi et al.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: amoxicillin; fatty acid; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase; lipoprotein; pefloxacin; phospholipid; triacylglycerol; 3-hydroxy-3-methylglutaryl-coenzyme A; acyl coenzyme A; amoxicillin; antiinfective agent; cholesterol; pefloxacin; phospholipid, animal cell; animal experiment; animal tissue; Article; cholesterol synthesis; controlled study; diet restriction; down regulation; dyslipidemia; erythrocyte; hypertriglyceridemia; lipid metabolism; lipidosis; male; nonhuman; rat; upregulation; animal; biosynthesis; blood; brain chemistry; cardiac muscle; chemistry; drug effects; kidney; liver; lung; metabolism; spleen, Animalia; Rattus, Acyl Coenzyme A; Amoxicillin; Animals; Anti-Bacterial Agents; Brain Chemistry; Cholesterol; Erythrocytes; Kidney; Liver; Lung; Male; Myocardium; Pefloxacin; Phospholipids; Rats; Spleen
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Solomon Rotimi
Date Deposited: 18 Jun 2021 16:02
Last Modified: 18 Jun 2021 16:02

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