Oladejo, David Oladoke and Oduselu, G. O and Dokunmu, Titilope M. and Isewon, Itunuoluwa and Okafor, Esther and Iweala, E. E. J. and Adebiyi, E. F. (2021) In Silico Evaluation of Inhibitors of Plasmodium Falciparum AP2-I Transcription Factor and Plasmodium Falciparum Bromodomain Protein 1. Research Square.
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Abstract
Recent treatment failures observed for Artemisinin-based combination therapy (ACT) have raised concerns about the efficacy of the front-line drug to treat malaria and the need to develop a new antimalarial drug regimen. Plasmodium falciparum Apicomplexan Apetala 2 Invasion (PfAP2-I) transcription factor (TF) is a protein that regulates the expression of a subset of gene families involved in Plasmodium falciparum red blood cell (RBC) invasion. PfAP2-I associates with several chromatin proteins, including the Plasmodium falciparum bromodomain protein 1 (PfBDP1) and that complex formation is associated with transcriptional regulation. Inhibiting PfAP2-I TF and PfBDP1 with small molecules represents a potential new antimalarial therapeutic target to combat drug resistance, which this study aims to achieve.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Electronics and Computer Science |
| Depositing User: | Mrs Patricia Nwokealisi |
| Date Deposited: | 31 Mar 2022 13:24 |
| Last Modified: | 31 Mar 2022 13:24 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/15777 |
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