OGUNRINOLA, GRACE AYOOLUWA and Covenant University, Theses (2020) PREVALENCE OF FEMALE UROGENITAL TRACT INFECTIONS IN ADO- ODO/OTA, OGUN STATE. Masters thesis, COVENANT UNIVERSITY.
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Abstract
Urinary tract infections (UTI) represent one of the most frequent reasons for hospital outpatient visits. Over 1 million women worldwide experience an episode of acute Pelvic Inflammatory Disease (PID) each year with higher prevalence recorded amongst teenagers and first-time mothers. This study assessed the prevalence of urogenital tract infections among symptomatic and asymptomatic females, in Ado-Odo Ota Local Government Area of Ogun State. Ethical approval was obtained from Covenant University Health Research and Ethics Committee. A total of 120 consenting females 13 years and above were recruited into this study. Midstream urine and high vaginal swabs (HVS) were collected alongside demographic information and medical history using structured questionnaires. Obtained samples were analysed using standard microbiological techniques. Antibiotic susceptibility pattern of obtained isolates was assessed using disc diffusion method. Plasmid profiling of multidrug-resistant isolates was carried out. The overall prevalence of UTI in this study was 66.9% with the symptomatic participants accounting for the highest prevalence (77.67%) as compared with the asymptomatic participants (56.7%). A total of 145 isolates were obtained from urine and high vaginal swab collected. Escherichia coli was the most frequently isolated organism from both urine (54%) and high vaginal swabs (20%) samples. Antibiotic resistance among the Gram- negative isolates was highest to Ampicillin (76.31%) and Augumentin (64.75%) and lowest to Nitofurantion (9.48%), Ciprofloxacin (15.36%) and Gentamicin (24.51%). Gram-positive isolates showed higher resistance to Cloxacillin (100%), Ceftazidime (87.5) and Gentamicin (87%). Plasmid profiling revealed that the antibiotic resistance seen in 11.2% of the isolates were plasmid-borne. Conjugation analysis also revealed that these isolates were capable of transferring plasmids via conjugation. This study has shown that there is a high prevalence of urogenital tract infection and antimicrobial-resistant pathogensin the study area. Findings from this study necessitate awareness and interventions towards antibiotic stewardship in a bid to prevent the spread of multidrug resistant species.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Urogenital Tract Infections, Symptomatic, Asymptomatic, Antimicrobial resistance, Plasmids |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 27 May 2022 15:15 |
| Last Modified: | 27 May 2022 15:15 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/15896 |
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