Nkongho, Sonia and Covenant University, Theses (2022) THERMODYNAMIC MODELLING OF LIQUID-LIQUID EXTRACTION OF LIMONOIDS FROM Azadirachta indica. Masters thesis, Covenant University Ota.
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Abstract
Limonoids from Azadirachta indica (also known as dongoyaro in Nigeria) leaves are separated using features of phase equilibrium including partition coefficients pressure, temperature, compositions, and partition coefficients when constructing chemical separation operations for limonoids from the leaves. In order to determine the thermodynamic properties, the ternary liquid-liquid behaviors in the system (n-hexane + limonoids + water) at 323.15 K and 373.15 K, and constant pressure of 101.3 kPa was modeled and simulated. Comparisons were made between the effects of extraction and the system's calculated partition coefficient (D) and selectivity (S). The Othmer-Tobias correlation was employed to evaluate the regularity and dependability of empirical liquid-liquid equilibrium (LLE) data. The empirical data were compared utilizing the Non-Random Two-Liquids (NRTL) and Universal Quasichemical (UNIQUAC) models, whereas the binary interaction parameters (BIPs) specified for each model were derived utilizing regression in the ASPEN plus software. The separation factor values which ranged from 0.9110 to 18.2177 demonstrated to be temperature and concentration of limonoid dependent. In accordance with the Othmer-Tobias equation, the authenticity of the LLE data had a regression coefficient greater than 0.8553. Equally, the NRTL model was the best fit for the prediction of the extraction of limonoids from neem leaves since the Root Mean Square Regression Deviation (RMSD) values between the experimental and calculated LLE data of less than 0.1847 percent as compared to 0.7501 percent using UNIQUAC model. The results obtained can be used in pharmaceutical industries in the design of the extraction column to produce high purity limonoids for the treatment of malaria which will influence the design, procedure, and enhancement of the process.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Thermodynamic liquid-liquid equilibrium, Azadirachta indica, Aspen Plus, NRTL, UNIQUAC |
| Subjects: | T Technology > TP Chemical technology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Engineering Sciences |
| Depositing User: | nwokealisi |
| Date Deposited: | 20 Sep 2022 15:30 |
| Last Modified: | 20 Sep 2022 15:30 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/16185 |
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