Oyekan, Josephine Oluwagbemisola and Covenant University, Theses (2024) SYNTHESIS AND EVALUATION OF ORGANIC FUNCTIONALISED MESOPOROUS (MCM-41) MATERIALS AS NANO-CARRIERS FOR ANTITUBERCULAR HYDRAZONE DRUG DERIVATIVES. ["eprint_fieldopt_thesis_type_phd" not defined] thesis, Covenant University.
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Abstract
The use of conventional drug delivery systems for the treatment and management of tuberculosis comes with setbacks that require the development of advanced drug delivery systems for the improved delivery of anti-tubercular agents. Mesoporous silica nanoparticles (MCM-41) have been of great interest as they possess distinctive properties that give them an edge over conventional drug delivery systems. This study focuses on the sol-gel synthesis and amino functionalisation of mesoporous silica nanoparticles via co-condensation and post-grafting methods to deliver anti-tubercular agents such as isoniazid and its metal complexes. Non-functionalised and amino functionalised MCM-41 nano-carriers were synthesised from two silica sources (tetra ethyl orthosilicate and sodium silicate) and characterized with X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) surface analysis, Fourier-transform infrared spectroscopy (FT-IR), CHNS analysis, Scanning electron microscopy (SEM), Transmission Electron Microscopy (TEM) and Thermo-gravimetric analysis (TGA). The physical and morphological properties of the drug loading and release studies of the nano-carriers synthesised from different silica sources were compared. Non-functionalised and amino functionalised nano-carriers synthesised with Tetra Ethyl Ortho Silicate were revealed to have better well-ordered pores than those synthesised using sodium silicate from their XRD analysis. The morphological characterisation of the nano-carriers using SEM showed that the surfactant removal methods (calcination and acid/ethanol extraction) affected their structural properties. Nano-carriers, Cal-MCM-41t&s + Cu-INH and Post-NH2-Cal-MCM-41t&s + Cu-INH had high drug entrapment efficiencies of 87.65%, 76.23% and 92.82%, 90.2% with loading capacities of 17.53%, 15.25% and 18.66%, 18.05%. Amino-functionalised nano-carriers were shown to improve the drug loading and entrapment efficiency of the nano-carriers. The in-vitro release study revealed a steady release rate of anti-tubercular agents INH, Cu-INH, and Fe-INH. Cal-MCM-41t&s + Cu-INH and Post-NH2-Cal-MCM-41t&s + Cu-INH released the highest amount of INH and its metal complexes. Cal-MCM-41t + Cu-INH, Post-NH2-Cal-MCM-41t + Cu-INH, Cal-MCM-41s + Cu-INH and Post-NH2-Cal-MCM-41s + Cu-INH released 30.97%, 36.43%, 41.98% and 50.82% at a pH of 7.4 while at a pH of 5.4, they released 39.54%, 47.26%, 52.82% and 66.74% respectively after 14 days. The findings showed that using non-functionalised and amino-functionalised mesoporous silica nano-carriers is a promising drug delivery system for delivering isoniazid and its metal complexes. However, other surface-functionalised MCM-41 nano-carriers should also be studied.
| Item Type: | Thesis (["eprint_fieldopt_thesis_type_phd" not defined]) |
|---|---|
| Uncontrolled Keywords: | Tuberculosis, Mesoporous silica nano-carriers, Isoniazid, Metal complexes Drug delivery |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Patricia Nwokealisi |
| Date Deposited: | 05 Jul 2024 15:24 |
| Last Modified: | 05 Jul 2024 15:24 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/18153 |
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