Ajani , Olayinka O.
MICROWAVE-ASSISTED SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME PYRAZOL-1-YLQUINOXALIN-2(1H)-ONE DERIVATIVES.
Chemistry of Heterocyclic Compounds, 45 (11).
ISSN 0009 - 3122
PDF (This paper describes the microwave assisted synthesis of bioactive quinoxaline incorporated with pyrazole and the antibacterial study of the newly synthesized compounds)
- Published Version
3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active with an MIC value of 7.8 μg/ml.
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