Ajani , Olayinka O. (2009) MICROWAVE-ASSISTED SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME PYRAZOL-1-YLQUINOXALIN-2(1H)-ONE DERIVATIVES. Chemistry of Heterocyclic Compounds, 45 (11). pp. 1370-1378. ISSN 0009 - 3122
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PDF (This paper describes the microwave assisted synthesis of bioactive quinoxaline incorporated with pyrazole and the antibacterial study of the newly synthesized compounds)
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Abstract
3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active with an MIC value of 7.8 μg/ml.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3-hydrazinoquinoxalin-2(1H)-one, imines, Gram-positive bacteria |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mr Olayinka O. AJANI |
| Date Deposited: | 30 Jun 2011 17:30 |
| Last Modified: | 13 Dec 2011 21:13 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/355 |
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