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Complex-Induced Proximity Effect in Lithiation: Unveiling Recent Potentials in Organic Synthesis of Biologically Relevant Heterocyclic Compounds

Ajani, Olayinka O. and Shomade, M.O and Edobor-Osoh, A. and Ajanaku , C. O. and Ajani, Alice O (2015) Complex-Induced Proximity Effect in Lithiation: Unveiling Recent Potentials in Organic Synthesis of Biologically Relevant Heterocyclic Compounds. The Open Organic Chemistry Journal, 9. pp. 1-8. ISSN 1874-0952

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Abstract

Reactions that convert carbon–hydrogen (C–H) bonds into carbon–carbon (C–C) or carbon–heteroatom (C–Y) bonds are attractive tools for organic chemists, potentially expediting the synthesis of target molecules via functional group interconversion. More explorative studies have shown Complex Induced Proximity Effect (CIPE) to be a solutionprovider for the synthesis of bioactive compounds. This might act as excellent pathfinders to new drugs for combating microorganisms’ resistance challenges to old existing drug. So, a constant review into CIPE and lithiation chemistry is crucial because they offer excellent pathways to new heterocyclic compounds which are essential agents in drug design and discovery.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: Mrs C.O. Ajanaku
Date Deposited: 09 Apr 2015 09:59
Last Modified: 09 Apr 2015 09:59
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/4748

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