SYNTHESIS OF (E)-N'-(5-bromo-SYNTHESIS OF (E)-N'-(5-bromo-2-hydroxybenzylidene)nicotinohydrazide) AND ITS Pt(II), Zn(II), Mn(II), Ni(II) AND Mo(V) COMPLEXES AS POTENTIAL ANTI-TUBERCULAR AGENT AGENT

Ogunniran, K. O. and Mesubi, M. A. and Adekoya, J. A. and Siyanbola, T. O. and Inegbenebor, A. I. and Ojo, O. O. and Adedapo , E.A. and Edobor-Osoh, A. and Narender, T. (2015) SYNTHESIS OF (E)-N'-(5-bromo-SYNTHESIS OF (E)-N'-(5-bromo-2-hydroxybenzylidene)nicotinohydrazide) AND ITS Pt(II), Zn(II), Mn(II), Ni(II) AND Mo(V) COMPLEXES AS POTENTIAL ANTI-TUBERCULAR AGENT AGENT. Canadian Journal of Pure and Applied Sciences, 9 (2). pp. 3519-3534. ISSN 1920-3853; Print ISSN: 1715-9997

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Abstract

The cold condensation reaction of nicotinic acid hydrazide and 5-bromo-2-hydoxylbenzaldehyde to form a tridentate Schiff base hydrazone ligand {H2L3 ) was studied. The prepared ligand was characterized using CHN analyzer, ESI mass spectrometry, IR, 1H NMR, 13C NMR and 2D NMR such as COSY and HSQC. Thereafter, five novel metal complexes [Pt(Il), Zn(ll), Mn{ll), Ni(JJ) and Mo(V)] of the hydrazone ligand were synthesized and characterized based on conductivity measurements, CHN analysis, AAS, magnetic measurement, UV/ Vis, IR, ESR and TGAIDTA study. The proposed structures of the metal complexes were further supported with the use of powder X-ray analysis. Antitubercular activity study of the compounds was evaluated against Mycobac/erium Juberculosis H37Rv by using microdiluted method. The study revealed that H2L3 exhibited promising anti-tubercular activity with MlC value of 0.82 j.igfmL. Also, metal complexes {(Pt(H2L3)Cl]- 0.88 IJg/mL, [Mn{H2L3)(CH3C00)2]- 0.78 JJ.g/mL, [Zn(H2e)(CH3C00)2H20]- 0.62 J.Lg/mL and [Ni{H2L3)(CI)2]H20- 1.19 J.Lg/mL) exhibited significant inhibition as compared to the standard drug (isoniazid- 0.91 j.ig/mL). Complex 2 and 3 with coordinated acetates showed two folds inhibition than standard isoniazid drug. However, complex 5 with coordinated chlorine atom displayed lower inhibition when compared to isoniazid.

Item Type:	Article
Uncontrolled Keywords:	X-ray, hydrazones, metal complexes, electron spin resonance, thermogravimetric, crystallographic. anti-tubercular agents.
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	Mrs Patricia Nwokealisi
Date Deposited:	11 Aug 2015 13:16
Last Modified:	16 Jan 2017 12:27
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/5390

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