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Bioactive compounds from Rumex plants

Liang, Heng-Xing and Dia , Huan-Qin and Fu , Hai-An and Adebayo, H. A. and Zhang, Li Xin and Cheng, Yong-Xian (2010) Bioactive compounds from Rumex plants. Phytochemistry Letters , 2010 (3). pp. 181-184.

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Two new naphthalene acylglucosides, rumexneposides A (1) and B (2), together with 12 known compounds (3-14), were isolated from the roots of Rumex nepalensis. Their structures were established by chemical and spectroscopic methods. The biological activities of compounds 1-14 as well as an additional 11 compounds previously isolated from R. nepalensis and Rumex hastatus (15–25) were evaluated against Mycobacterium tuberculosis, para-aminobenzoic acid (pAba) pathway, and a panel of human cancer cell lines. The results showed that compound 15 was the most active against M. tuberculosis with an MIC value of 2.85 mM similar to that of isoniazid. Compound 5 could inhibit pAba synthetic pathway with an MIC value of 12.6 mM, comparable to that of positive control abyssomicin C, representing a new example of the rare pAba pathway inhibitors.

Item Type: Article
Uncontrolled Keywords: Rumex nepalensis Rumex hastatus Polygonaceae Rumexneposides A and B Anti-tuberculosis pAba pathway inhibitor Cytotoxicity
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Aderonke Olufunke Asaolu
Date Deposited: 11 Mar 2016 08:22
Last Modified: 11 Mar 2016 08:22

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