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Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae)

Adebayo , H. A. and Akindahunsi , A. A and Zeng, Guang-Zhi and Zhang, Yu-Mei (2010) Anticancer and antiradical scavenging activity of Ageratum conyzoides L. (Asteraceae). Pharmacognosy Magazine, 6 (21). pp. 62-66. ISSN 0973-1296

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Abstract

Ageratum conyzoides has been used in folklore for the treatment of a wide range of diseases. In the present investigation, the in vitro activity of ethanol, petroleum ether, ethylacetate, butanol, and water extracts of A. conyzoides were screened in some cancer cell lines using the sulphorhodamine B (SRB) assay. These cell lines include: Human non-small cell lung carcinoma (A-549), human colon adenocarcinoma (HT-29), human gastric carcinoma (SGC-7901), human golima (U-251), human breast carcinoma (MDA-MB-231), human prostate carcinoma (DU-145), human hepatic carcinoma (BEL-7402), and mouse leukemia (P-388) cancer cell lines. Furthermore, kaempferol was isolated from the ethylacetate extract and the structure was elucidated by nuclear magnetic resonance (NMR) and mass spectroscopy. The effect of DPPH antiradical activity on the extracts and kaempferol was also determined. The results showed that ethylacetate extract exhibited the highest cytotoxic activity on A-549 and P-388 cancer cells with IC50 values of 0.68 and 0.0003 �g/ml, respectively. Kaempferol isolated from the ethylacetate extract of A. conyzoides rapidly scavenged DPPH at a concentration of 130.07 ± 17.36 g/ kg. The result therefore showed that A. conyzoides possessed anticancer and antiradical properties.

Item Type: Article
Uncontrolled Keywords: Ageratum conyzoides, anticancer, antiradical scavenging activity, cytotoxicity
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Aderonke Olufunke Asaolu
Date Deposited: 15 Mar 2016 12:15
Last Modified: 15 Mar 2016 12:15
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/6474

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