The Effects of Ethanolic Leaf Extract of Commiphora africana (Burseraceae) on Rat Liver and Kidney Functions

Aliyu, R. and Adebayo, H. A. and Garba, H. I. (2007) The Effects of Ethanolic Leaf Extract of Commiphora africana (Burseraceae) on Rat Liver and Kidney Functions. Journal of Pharmacology and Toxicology , 2 (4). pp. 373-379. ISSN 1816-496X

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Abstract

The effects of Commiphora africana ethanolic leaf extract on some biochemical markers of liver and kidney functions were investigated in rats. The results showed a significant (p<0.05) decrease in serum albumin after 10 days of treatment for the group administered 100 mg kg-1 body weight of the extract. There was no significant (p>0.05) change in alkaline phosphatase activity, while groups administered 100 and 150 mg kg-1 showed significant (p<0.05) increases in serum total bilirubin, after 10 days of treatment. Also, aspartate aminotransferase activity was significantly increased in groups administered 100 mg kg-1 (p<0.01) and 150 mg kg-1 (p<0.05), while alanine aminotransferase showed no significant (p>0.05) increase. The group administered 25 mg kg-1 showed significant (p<0.05) increase in serum creatinine after 24 h of treatment. The results of the liver and kidney histology showed that there was no noticeable damage to the liver tissues of rats administered the extract. However, hydropic degeneration of the cortical-tubular epithelium and glomerulus was seen with the group administered 100 mg kg-1. Similarly, the group treated with 150 mg kg-1 showed acute glomerulonephritis and proliferation of the mesangial cells. These results suggest that C. africana extract may enhance liver function at low doses and may cause adverse effects at high doses.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology Q Science > QR Microbiology
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	Mrs Aderonke Olufunke Asaolu
Date Deposited:	15 Mar 2016 12:38
Last Modified:	15 Mar 2016 12:38
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/6475

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