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Acetaminophen Induces Mitochondrial Permeability Transition in Rats Without Causing Necrotic Liver Damage

Iyanda-Joel, Wisdom and Adegbite, Oluwatobi and Akinsanya, Yetunde Ifeoma and Aka, Babafemi and Mogbo, Princessca and Yakubu, Omolara Faith and Oladipo, Blessing and Afolabi, Blessing and Kukoyi, Ayobami Jahdahunsi and Omiyale, Benjamin and Iyoha, Alex and Maduagwu, E. N. (2016) Acetaminophen Induces Mitochondrial Permeability Transition in Rats Without Causing Necrotic Liver Damage. Journal of Biological Sciences. pp. 22-29. ISSN 1727-3048

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Abstract

Mitochondrial Permeability Transition (MPT) is reported as the mechanism of acetaminophen induced hepatic damage, however, rat models are resistant to acetaminophen induced toxicity. The occurrence and degree of mitochondrial permeability transition after treatment with 400 mg kgG1 of acetaminophen in albino Wistar rats were assessed. Animals were randomly distributed into seven groups; control, 12, 24, 36, 48, 60 and 72 h based on varying time (in hour) post acetaminophen prior to sacrifice after treatment. Mitochondrial Membrane Permeability Transition (MMPT) pore opening and mitochondrial cytochrome c release were estimated. Opening of MMPT pore and cytochrome c release were observed in 12, 24, 36 and 72 h, when compared with the control group. Liver function and histological results indicated no liver damage. It is concluded that toxic dose of acetaminophen induced mitochondrial permeability transition in rat hepatic tissues without leading to necrotic damage suggesting that rat hepatic tissues evade damage by mechanisms downstream of MPT.

Item Type: Article
Uncontrolled Keywords: Acetaminophen, mitochondrial permeability transition, cytochrome c, necrosis, ALT, ALP
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QR Microbiology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 20 Sep 2016 15:08
Last Modified: 20 Sep 2016 15:08
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/7223

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