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Hepatotoxicity of dimethylnitrosamine in cats and lizards

Maduagwu, E. N. and Anosa, Victor O. (1981) Hepatotoxicity of dimethylnitrosamine in cats and lizards. Toxicology Letters, 9 (1). pp. 41-44.

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The hepatotoxic effects of the oral administration of a single dose of 50 mg dimethylnitrosamine DMN)kg and daily doses of 5 mg and 1mgkg, respectively, to cats and lizards were studied by light microscopy. Centrilobular necrosis was the main alteration detected in the liver of cats as in other animal species studied. The lizards, however, appeared unaffected. Morphological changes observed in the liver of these reptiles included haemorrhage, vacuolation of hepatocytes and diffuse nuclear changes; including pyknosis, karyorrhexis and karyolysis. Haemorrhage was also evident in the liver of cats as well as leukocytic infiltration; including macrophages, lymphocytes and neutrophils. Cats appeared to be more susceptible to DMN poisoning

Item Type: Article
Uncontrolled Keywords: DMN; dimethylnitrosamine
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 24 Mar 2017 12:30
Last Modified: 24 Mar 2017 12:30

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