Adebayo, H. A. and Ashano, Efejiro and Yakubu, Omolara Faith and Okubena, O. (2017) Pro-inflammatory and toxicological evaluation of Hepacare in mice. Journal of Taibah University Medical Sciences, 12 (4). pp. 313-323.
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Abstract
Objectives: Hepacare! is a widely marketed herbal formulation in Nigeria for treating chronic liver ailments. This study evaluated the safety, as well as pro- inflammatory and genotoxicity effects, of Hepacare! in mice. Methods: The effect of the formulation was estimated in a 28-day study where 25 mice were divided into five groups, and Hepacare! was orally administered at 250, 500, 750 and 2500 mg/kg body weight. The biochemical and haematological parameters were determined, organ weights were estimated and histopathology was also conducted. mRNA expression of the pro-inflammatory cytokines, TNF-a and IL-6 was estimated by RT-PCR in acute toxicity experiments. Results: The LD50 was calculated at 3807.89 mg/kg body weight in mice. There was a significant increase (p < 0.05) in the ALP activity in the 750 mg/kg treated group, while the 2500 mg/kg group exhibited significant increases in their AST, ALT, ALP, total bilirubin and total protein levels compared with the control group. However, there was a significant dose related increase in monocytes
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mr Adewole Adewumi |
| Date Deposited: | 29 Aug 2017 10:28 |
| Last Modified: | 29 Aug 2017 10:28 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/8964 |
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