PHYTOCHEMICAL SCREENING AND IN VIVO ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CAESALPINIA BONDUC (L.) ROXB

Ogunlana, Olubanke Olujoke and Ogunlana, Oluseyi Ebenezer and Ntube , C. A and Olagunju , J. A and Akindahunsi, A. A. (2012) PHYTOCHEMICAL SCREENING AND IN VIVO ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CAESALPINIA BONDUC (L.) ROXB. Global research journal of PHARMACEUTICAL SCIENCES, 1 (1). pp. 1-5.

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Abstract

Phytochemical screening, antioxidant activity in vivo and lipid peroxidation of 75 % ethanolic extract of young twigs and leaves of Caesalpinia bonduc were carried out by chemical test, and assessment of catalase and peroxidase activities and lipid peroxidation in Wistar rats after oral administration of different concentrations of the plant extract for ten days. Phytochemical screening of the extract revealed the presence of all major classes of phytochemicals: tannins, flavonoids, saponin, steroids, terpenoids, cardiac glycosides, glycosides, except phlobatannins. There were significant (p<0.05) graded increase in catalase and peroxidase activities and decrease in TBARS concentrations in the extract tested rats in comparison with normal control, Vitamin C and amodiaquine tested rats. The various pharmacological activities of C. bonduc may be due to its antioxidant activity.

Item Type:	Article
Uncontrolled Keywords:	Caesalpinia bonduc, Catalase, Peroxidases, Antioxidant activity.
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Mrs Patricia Nwokealisi
Date Deposited:	25 Jun 2018 10:19
Last Modified:	25 Jun 2018 10:19
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/11031

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