Abstract B048: Androgen metabolism and incidence of prostate cancer in Nigeria

Rotimi, S. O and Ogo, Chidiebere and Ogunlana, Olubanke Olujoke and Chinedu, S. N. and Iweala, E. E. J. (2018) Abstract B048: Androgen metabolism and incidence of prostate cancer in Nigeria. In: AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research, December 2-5, 2017, Orlando, Florida.

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Abstract

The risk of prostate cancer among blacks, especially of Nigerian descent, is higher than other races. This could be attributed to biologic and genetic variability. The role of androgen metabolism in prognosis of prostate cancer has been delineated and reported. One of the enzymes involved in androgen metabolism is CYP3A4, which has not been studied in Nigerian men afflicted with prostate cancer. Racial differences in this functional gene may contribute to variations in incidence of prostate cancer across ethnic divides. Therefore, identifying a diagnostic and prognostic biomarker such as CYP3A4 polymorphism for prostate cancer in black men will improve the treatment and management of the disease. In this study, we investigated the genotypes of CYP3A4 of prostate cancer patients from Nigeria for possible correlation to the high incidence of the disease in Nigerian men. The results obtained showed a preponderance of the GG genotypes, which indicates a possible correlation between this genotype of CYP3A4 and higher risk of prostate cancer among Nigerian men.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User:	Mrs Patricia Nwokealisi
Date Deposited:	11 Mar 2020 11:35
Last Modified:	11 Mar 2020 11:35
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/13190

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