Obi, Patience O. and Covenant University, Theses (2019) ASSOCIATION OF HAPTOGLOBIN GENOTYPES, BREAST CANCER AND MALARIA IN A POPULATION OF NIGERIAN WOMEN. Masters thesis, COVENANT UNIVERSITY.
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Abstract
Breast cancer is the leading cause of mortality among women with over a million cases recorded globally. Haptoglobin (Hp) is an acute phase glycoprotein whose major role is to remove free hemoglobin from circulation. The prevalence of Hp genotypes varies between populations from different countries and ethnic groups. Several studies have investigated the association of haptoglobin genotypes with breast cancer occurrence, but have reported conflicting results. However, only few studies have investigated the incidence of Hp genotypes, and their association to breast cancer occurrence and malaria in Nigeria. In this study, the association of haptoglobin genotypes, breast cancer and malaria was investigated among healthy women and clinically diagnosed breast cancer patients. Blood samples were collected from Lagos and Ogun States, and DNA was extracted using standard methods. Haptoglobin genotypes and malaria were detected by polymerase chain reaction (PCR) and agarose gel electrophoresis in breast cancer patients (n=75) and healthy controls (n=287). The percentage distribution of the 362 women that participated in the study was as follows: Hp 2-1 (39.8%) genotype had the highest prevalence, followed by Hp 1-1 (34.5%), and Hp 2-2 (25.7%). A highly significant increase in Hp 1-1 genotype (P<0.05) was observed among patients in the BC group when compared with the control group. Furthermore, a higher frequency of Hp 1 allele (54.4%) than Hp 2 allele (45.6%) was observed from both groups. However, no significant difference was observed in Hp 1 allele among the BC group when compared with the control group. A significant increase in Hp 1 allele (P<0.05) was observed among malaria-positive patients in the control group. An increase in Hp 1 allele was also observed in BC group, but it was not significant. The result of this study suggest an association between Hp 1-1 genotype and breast cancer occurrence, and an association between Hp 1 allele and increased risk of malaria infection.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Breast cancer, haptoglobin, malaria, genotype, allele |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mrs Hannah Akinwumi |
| Date Deposited: | 25 Jun 2020 10:45 |
| Last Modified: | 25 Jun 2020 10:45 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/13415 |
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