Erythrocyte acetylcholinesterase activity as a surrogate indicator of lead-induced neurotoxicity in occupational lead exposure in Abeokuta, Nigeria

Ademuyiwa, O. and Ugbaja, R.N. and Rotimi, S.O. and Abam, E. and Okediran, B.S. and Dosumu, O.A. and Onunkwor, B.O. (2007) Erythrocyte acetylcholinesterase activity as a surrogate indicator of lead-induced neurotoxicity in occupational lead exposure in Abeokuta, Nigeria. Environmental Toxicology and Pharmacology, 24 (2). pp. 183-188.

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Abstract

Dose-effect and dose-response relationships in occupational neurotoxicology are rarely studied by means of biochemical methods. In order to investigate the potential neurotoxic effects of lead during occupational exposure to this metal, the activity of erythrocyte acetylcholinesterase (AcChE), as well as blood pressure and pulse, were determined in various artisans in Abeokuta, Nigeria, who have been shown to be occupationally exposed to lead, and these were related to blood lead levels. AcChE activity in the artisans was inhibited to varying extents. While AcChE activity was inhibited to the tune of 39 in the male petrol station attendants, the inhibition amounted to 32 in female petrol station attendants. In other artisans, AcChE inhibition ranged from 31 in the welders to 38 in painters. The lowest inhibition of 15 was obtained in the panel beaters. Correlations, as calculated by Pearson's method, revealed a significant (p < 0.001) inverse linear relationship between AcChE activity and blood lead levels (r = -0.40; y = -120.38x + 13935.59; p < 0.001). Blood pressure and pulse were not significantly different between control and lead-exposed subjects. Our findings suggest that erythrocyte AcChE activity could be used as a biomarker of lead-induced neurotoxicity in occupationally exposed subjects. © 2007 Elsevier B.V. All rights reserved.

Item Type:	Article
Additional Information:	cited By 45
Uncontrolled Keywords:	acetylcholinesterase; lead, adolescent; adult; aged; article; blood pressure; controlled study; demography; enzyme activity; erythrocyte; female; human; male; neurotoxicity; Nigeria; priority journal; pulse rate
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	Solomon Rotimi
Date Deposited:	18 Jun 2021 16:24
Last Modified:	18 Jun 2021 16:24
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/14670

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