Effect of aqueous extract of momordica charantia on survival, locomotive behaviour and antioxidant status of drosophila melanogaster

De-Campos, O.C. and Layole, M.P. and Iheagwam, F.N. and Rotimi, S.O. and Chinedu, S.N. (2021) Effect of aqueous extract of momordica charantia on survival, locomotive behaviour and antioxidant status of drosophila melanogaster. Tropical Journal of Natural Product Research, 5 (1). pp. 178-181.

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Abstract

Momordica charantia, commonly known as bitter gourd, is a therapeutic plant popularly known for its antidiabetic potential in folklore medicine. This study investigated the effect of aqueous leaf extract of M. charantia (AMC) on survival rate, locomotive behaviour and antioxidant response in Drosophila melanogaster. Adult flies were fed with different concentrations of AMC (0-100 mg/mL) for 12 days, and their locomotive behaviour and whole-body antioxidant status were assessed at 0, 2, 4 and 8 mg/mL of AMC. Results showed a significant decrease (p < 0.05) in the survival rate and locomotive behaviour of flies at 8, 16 and 50 mg/mL of AMC compared to the control. There was no significant difference in malondialdehyde content, GSH level and SOD activity of flies exposed to 2, 4, and 8 mg/mL of AMC compared to the control group. Glutathione-s-transferase activity at 8 mg/mL of AMC increased significantly (p < 0.05) when compared to the control group. Acetylcholinesterase activity also increased in a dose-dependent manner with a significant increase at 4 and 8 mg/mL of AMC. The evidence from this study suggests that low to moderate doses of aqueous extract of Momordica charantia slightly improved survival rate of flies. It also increased the activities of acetylcholinesterase and antioxidant enzymes. © 2021 the authors and De-Campos et al.

Item Type:	Article
Additional Information:	cited By 0
Uncontrolled Keywords:	acetylcholinesterase; antioxidant; edetic acid; glutathione peroxidase; glutathione transferase; malonaldehyde; Momordica charantia extract; protein; sodium hydroxide; sucrose; superoxide dismutase, adult; antioxidant activity; Article; controlled study; Drosophila melanogaster; drug effect; female; lipid peroxidation; locomotion; male; Momordica charantia; mortality; nonhuman; plant leaf; spectrophotometry; survival; survival rate
Subjects:	Q Science > Q Science (General)
Divisions:	UNSPECIFIED
Depositing User:	Franklyn N IHEAGWAM
Date Deposited:	21 Jun 2021 15:59
Last Modified:	21 Jun 2021 15:59
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/14781

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