Iheagwam, Franklyn N and Obiageli Okeke, C. and Christianah Decampos, O. and Uche Okere, D. and Olujoke Ogunlana, O. and Nwodo Chinedu, S. (2019) Safety evaluation of Terminalia catappaLinn (Combretaceae) aqueous leaf extract: Sub-acute cardio-toxicopathological studies in albino Wistar rats. In: ICSSD 2019.
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Abstract
This study evaluated the safety of sub-acute administration of Terminalia catappa L. aqueous leaf extract (TCA) on cardiac biochemical parameters. Graded concentrations (200, 400 and 800 mg/kg) of TCA wereorally administered daily for 28 days. Cardiac biochemical parameters of toxicity were thereafter accessedusing standard methods forsuperoxide dismutase, peroxidase, glutathione-S-transferase, reduced glutathione, lipid peroxidation, protein levels, cholesterol, triglyceride, lactate dehydrogenase and creatinine kinase. TCA treatment did not alter the heart weight and cardiac biochemical parameters. Nonetheless, at 800 mg/kg, the antioxidant profile was significantly improved after TCA treatment. There was no mediated sign of treatment toxicityas well asa change in cardiac histological architecture. T. catappaaqueous leaf extract is relatively non-toxic to the heart at the experimental doses and also within the test period. © 2019 IOP Publishing Ltd. All rights reserved.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Additional Information: | cited By 0 |
| Uncontrolled Keywords: | Engineering research; Peptides; Planning; Sustainable development; Toxicity, Aqueous leaf extracts; Biochemical parameters; Cardiac; Glutathione S-transferases; Graded concentrations; Lactate dehydrogenase; sub-acute; Terminalia catappa L, Heart |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | UNSPECIFIED |
| Depositing User: | Franklyn N IHEAGWAM |
| Date Deposited: | 21 Jun 2021 16:38 |
| Last Modified: | 21 Jun 2021 16:38 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/14785 |
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