SOKOYA, IBUKUNOLUWA ADEDOYINSOLA and Covenant University, Theses (2022) CASE-CONTROL STUDY OF BUTYRYLCHOLINESTERASE ACTIVITY IN NIGERIAN BREAST CANCER PATIENTS. Masters thesis, COVENANT UNIVERSITY.
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Abstract
One-fourth of all incidences of cancer in women today are breast cancer (BC), making it one of the most prevalent types of cancer. The global public health burden of BC seems insurmountable especially in the underdeveloped world. Innovative tactics and approaches are required to promote the management of BC in Nigeria despite existing and previous research. Butyrylcholinesterase (BChE) is a soluble enzyme majorly synthesized in the liver and mainly found in the plasma that hydrolyses cholinergic esters. The activity of the enzyme has been linked to metabolic diseases, neurological disorders, cell differentiation, proliferation, and death. However, existing studies haven’t studied this enzyme in Nigerian BC patients. This study was done to inquire the activities of BChE in Nigerian BC patients (n = 100) and healthy control counterparts (n = 100) in relation with their ages (48 ± 12yrs and 46 ± 15yrs respectively), the stages of the cancer (Stages I – IV) and their body mass index (BMI) (28.1 ± 7.2 and 26.5 ± 6.8 respectively). The activity of BChE was determined by Ellman’s spectrophotometric analysis. There was no significant difference in the activity of BChE in Nigerian breast cancer patients when compared to their healthy control counterparts. However, the activity was observed to be higher in the test patients with an average of 1.61 μmol/min/ml. The changes in activity in comparison to the collective age groups, stages and BMI also did not show a significant change. However, the BChE activity was observed to be highest in age group 68-78yrs with an average activity of 2.18 μmol/min/ml, at Stage III of the breast cancer with 1.72 μmol/min/ml average activity and in overweight participants with an average activity of 1.76 μmol/min/ml. There is therefore only little prospect for the success of BChE as an appropriate biomarker for breast cancer management in Nigeria. However, the observed peculiarities can be further studied in conjunction with the genetic compositions of patients and enzyme.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Breast cancer, Biomarker, Butyrylcholinesterase |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | AKINWUMI |
| Date Deposited: | 06 Oct 2022 15:54 |
| Last Modified: | 06 Oct 2022 15:54 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/16286 |
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