Breast Cancer Phenotypes in Africa: A Scoping Review and Meta-Analysis

Onyia, Abimbola F. and Nana, Toluwani A. and Adewale, Elijah A. and Adebesin, Ayomide O. and Adegboye, Bose E and Paimo, Oluwatomiwa K. and De Campos, Opeyemi Christianah and Bisi-Adeniyi, Titilayo Ifeoluwa and Rotimi, Oluwakemi A and Oyelade, O. J. and Rotimi, S. O (2023) Breast Cancer Phenotypes in Africa: A Scoping Review and Meta-Analysis. ASCO JCO Global Oncology. pp. 1-10.

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Abstract

PURPOSE Africans have been associated with more aggressive forms of breast cancer (BC).However, there is a lack of data regarding the incidence and distribution of different subtypes on the basis of phenotypic classification. This scoping review and meta-analysis was undertaken to determine the distribution pattern of BC phenotypes (luminal, human epidermal growth factor receptor 2 [HER2]1, and triple-negative breast cancer [TNBC]) across the African region. METHODS Four online databases (PubMed, Scopus, ProQuest, and EBSCOhost) were accessed to identify studies published between 2000 and 2022 reporting the representation of receptor status (estrogen receptor, progesterone receptor, and HER2) in African patients with BC. Furthermore, the meta-analysis was carried out using a random-effects model and pooled using the inverse variance method and logit transformation. 95% CI and I2 statistics were calculated using the Clopper-Pearson method to estimate between-study heterogeneity. RESULTS A total of 2,734 records were retrieved, of which 2,133 were retained for further screening. After the screening, 63 studies were finally selected for the scoping review and meta-analysis. The pooled frequency of luminal, HER2-positive (HER21), and TNBC was estimated at 56.30%, 12.61%, and 28.10%, respectively.Northern Africa had the highest frequency of the luminal subtype, while West Africa showed higher frequencies of HER21 and TNBC subtypes. The review also had a representation of only 24 countries in Africa. CONCLUSION Our results highlight the disparity in the representation of molecular subtypes among the people in different regions of Africa. There is a need to incorporate routine molecular subtyping into the management of African patients with BC.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	AKINWUMI
Date Deposited:	05 Nov 2023 19:58
Last Modified:	05 Nov 2023 19:58
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/17489

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