OLUGBUYIRO, J.A.O (2009) AntiMtb activity of triterpenoid-rich fractions from Spondias mombin L. African Journal of Biotechnology, 8 (9). pp. 1807-1809. ISSN 1684-5315
|
PDF
- Published Version
Download (67Kb) | Preview |
Abstract
Spondias mombin L. used in traditional medicine because of its antimicrobial properties was found to contain cardiac glycosides, flavonoids, tannins, and anthraquinones in the stem bark. Bioassay-directed fractionation of the methanol extract of Spondias mombin was carried out with VLC and HPLC. Isolates were evaluated for antimtb activity which led to the isolation of a series of potential molecules. A semi pure triterpenoid that demonstrated potency of 92.8% inhibition against Mycobaterium tuberculosis (Mtb) at a concentration of 64μg/ml was further purified by HPLC. Keywords: Spondias mombin; Mycobaterium tuberculosis; Triterpenoids
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Olugbuyiro et al; Spondias mombin; Mycobaterium tuberculosis; Triterpenoids |
| Subjects: | Q Science > QD Chemistry Q Science > QK Botany R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | MR JOSEPH OLUGBUYIRO |
| Date Deposited: | 26 Aug 2011 11:10 |
| Last Modified: | 13 Dec 2011 21:14 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/506 |
Actions (login required)
 |
View Item |
