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AntiMtb activity of triterpenoid-rich fractions from Spondias mombin L.

OLUGBUYIRO, J.A.O (2009) AntiMtb activity of triterpenoid-rich fractions from Spondias mombin L. African Journal of Biotechnology, 8 (9). pp. 1807-1809. ISSN 1684-5315

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Abstract

Spondias mombin L. used in traditional medicine because of its antimicrobial properties was found to contain cardiac glycosides, flavonoids, tannins, and anthraquinones in the stem bark. Bioassay-directed fractionation of the methanol extract of Spondias mombin was carried out with VLC and HPLC. Isolates were evaluated for antimtb activity which led to the isolation of a series of potential molecules. A semi pure triterpenoid that demonstrated potency of 92.8% inhibition against Mycobaterium tuberculosis (Mtb) at a concentration of 64μg/ml was further purified by HPLC. Keywords: Spondias mombin; Mycobaterium tuberculosis; Triterpenoids

Item Type: Article
Uncontrolled Keywords: Olugbuyiro et al; Spondias mombin; Mycobaterium tuberculosis; Triterpenoids
Subjects: Q Science > QD Chemistry
Q Science > QK Botany
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User: MR JOSEPH OLUGBUYIRO
Date Deposited: 26 Aug 2011 11:10
Last Modified: 13 Dec 2011 21:14
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/506

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