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Antibacterial Activity of Culture Extracts of Penicillium chrysogenum PCL501: Effects of Carbon Sources

Onyegeme-Okerenta, B. M. and Chinedu, S. N. and Okafor, U. A. and Okochi, V. I. (2009) Antibacterial Activity of Culture Extracts of Penicillium chrysogenum PCL501: Effects of Carbon Sources. Online Journal of Health and Allied Sciences. ISSN 0972-5997

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Abstract

Penicillium chrysogenum PCL501 produced β-lactam antibiotics when fermented with different agro-wastes: cassava shavings, corncob, sawdust and sugarcane pulp. In vitro antibacterial activity of the culture extracts was tested against four clinical bacterial isolates, namely, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. All the culture extracts and standard drug (commercial Benzyl Penicillin) inhibited the growth B. subtilis and E. coli; the potency varied with carbon source. Antibacterial activity of extracts from cultures containing cassava shavings and sugarcane pulp was comparable with that of the standard drug. The MIC against the susceptible organisms was 0.20mg/ml for the standard drug and ranged from 0.40 to 1.50mg/ml for the culture extracts. Neither the culture extracts nor the standard drug inhibited K. pneumoniae and P. aeruginosa; the bacterial strains produced β-lactamase enzymes. Cassava shavings and sugarcane pulp are indicated as suitable cheap carbon sources for the production of antibiotics by Penicillium chrysogenum PCL501.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mr Adewole Adewumi
Date Deposited: 07 Feb 2011 14:41
Last Modified: 13 Dec 2011 21:13
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/51

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