Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics

Ajani, Olayinka O. and Isaac, Jessica T. and Owoeye, Taiwo F. and Akinsiku, A.A. (2015) Exploration of the Chemistry and Biological Properties of Pyrimidine as a Privilege Pharmacophore in Therapeutics. International Journal of Biological Chemistry, 9 (4). pp. 148-177. ISSN 1819-155X

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Abstract

The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1. Due to its prebiotic nature to living cells in biodiversity, it is an highly privileged motif for the development of molecules of biological and pharmaceutical interest. This present work deals with the exploration of chemistry and medicinal diversity of pyrimidine which might pave way to long await discovery in therapeutic medicine for future drug design.

Item Type:	Article
Uncontrolled Keywords:	Nitrogen heterocycle, biological activity, pyrimidine, anticancer, drug design
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	Mrs Patricia Nwokealisi
Date Deposited:	08 Oct 2015 15:20
Last Modified:	08 Oct 2015 15:20
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/5554

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