SIMULATION AND ANALYSIS OF PENTOSE PHOSPHATE PATHWAY IN PLASMODIUM FALCIPARUM USING COLORED PETRI NETS MODEL

Oyelade, O. J. and Isewon, Itunuoluwa and Mba-Kalu, S and Rotimi, S. O (2015) SIMULATION AND ANALYSIS OF PENTOSE PHOSPHATE PATHWAY IN PLASMODIUM FALCIPARUM USING COLORED PETRI NETS MODEL. THE JOURNAL OF COMPUTER SCIENCE AND ITS APPLICATIONS, 22 (2).

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Abstract

Plasmodium falciparum is a protozoan parasite and the deadliest of five human malaria species which is responsible for the majority of malaria related deaths in humans. The erythrocytes’ stage of Plasmodium falciparum depend on Pentose Pathway as an alternative source of energy and it releases electrons used in protecting the Plasmodium falciparum from its host. Colored Petri Net has been recognized as one of the important models in modelling and analyzing biological pathways. It is an accurate qualitative and quantitative modelling tool for modeling complex biological systems. In this work, the modeling of the pentose phosphate pathway in Plasmodium falciparum is presented using the Petri Net Markup Language (PNML). The Colored Petri Net (CPN) models based on the Petri Net representation and the conservation and kinetic equations were used to examine the dynamic behavior of the metabolic pathway. The usefulness of Petri Nets is demonstrated for the quantitative analysis of the pathway. We obtained data from Biocyc database. The constructed model was viewed through the Colored Petri Net Tool (CPN tool 4.0). Specific drug targets called the essential reactions within the pathway were identified, listed and proposed. These essential reactions would alter the functioning of the pathway which would affect the energy and protection needs of the parasite therefore leading to the death of the parasite in the human red blood cell.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	Mrs I. M. Isewon
Date Deposited:	08 Mar 2016 09:19
Last Modified:	19 Jul 2022 13:45
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/6404

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