In vitro antibacterial and antifungal activities of Chrysophyllum albidum and Diospyros monbuttensis leave

Olasehinde, G. I and Okolie, Zeluch Vianne and Oniha, M. I. and Adekeye, B. Temitope and Ajayi, A. A. (2015) In vitro antibacterial and antifungal activities of Chrysophyllum albidum and Diospyros monbuttensis leave. Journal of Pharmacognosy and Phytotherapy, 7. ISSN 2141-2502

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Abstract

Despite progress in the development of antibacterial agents, there are still special needs to find new antibacterial agents due to the development of multidrug resistance by bacteria and fungi.This study was conducted to investigate and compare the in vitro antibacterial and antifungal activities of the methanolic and ethanolic extracts of the leaves of Chrysophyllumalbidum and Diospyrosmonbuttensis.Methanolic and ethanolic extracts of D. monbuttensis and C. albidum leaves were prepared using cold extraction method. Antimicrobial sensitivity testing was carried out using agar-well diffusion method against the following test organisms: Staphylococcus aureus, Streptococcus sp., Escherichia coli (Enteropathogenic), Klebsiellasp., Candida albicans and Aspergillusniger. Minimum inhibitory concentration of the extracts of D. monbuttensis and C. albidum leaves was determined using broth dilution method. S.aureus, Streptococcus sp., E. coli andKlebsiellasp. were sensitive to ethanolic leaf extract of C. albidum at 25, 50 and 100mg/ml respectively. Streptococcus sp.,E. coli (Enteropathogenic), Klebsiellasp. AndC. albicanswere sensitive to C. albidum at 25and 50mg/ml. A. niger showed resistance to both extracts at the different concentrations used. The MIC of the methanol and ethanol leaf extracts of D. monbuttensis and C. albidum against the test microorganisms ranged between 3.125 and 100mg/ml. This is indicative that D. monbuttensis and C. albidum leaf extracts can be used in the treatment of infections

Item Type:	Article
Uncontrolled Keywords:	Diospyrosmonbuttensis, Chrysophyllumalbidum,extracts,antimicrobial, antifungal
Subjects:	Q Science > QH Natural history > QH301 Biology
Divisions:	Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User:	Mrs Patricia Nwokealisi
Date Deposited:	31 Aug 2016 12:05
Last Modified:	31 Aug 2016 12:05
URI:	http://eprints.covenantuniversity.edu.ng/id/eprint/7053

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