Maduagwu, E. N. (2008) Nitrosation of quaternary ammonium compounds in vivo in the Wistar rat. Xenobiotica the fate of foreign compounds in biological systems, 15 (12). pp. 1061-1068.
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Abstract
1. Animals dosed orally with nitrite (1.5 × 10−3 mol/kg) and nonyl dimethylbenzylammonium bromide (2.9 × 10−4 mol/kg) exhibit liver damage within two hours; cetyl trimethylammonium bromide plus nitrite was not significantly hepatotoxic. 2. Both nonyl dimethylbenzyl ammonium bromide and cetyl trimethylammonium bromide were demethylated by rat-liver microsomal preparations; substrate concentrations of 1 mM or more were inhibitory. 3. Bile from rats given i.p. doses of cetyl trimethylammonium bromide, nonyl dimethylbenzylammonium bromide or dodecyl dimethylbenzylammonium bromide contains only metabolites, no unchanged compounds were detected.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences |
| Depositing User: | Mrs Patricia Nwokealisi |
| Date Deposited: | 23 Mar 2017 11:18 |
| Last Modified: | 23 Mar 2017 11:18 |
| URI: | http://eprints.covenantuniversity.edu.ng/id/eprint/8011 |
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