University Links: Home Page | Site Map
Covenant University Repository

Nitrosation of quaternary ammonium compounds in vivo in the Wistar rat

Maduagwu, E. N. (2008) Nitrosation of quaternary ammonium compounds in vivo in the Wistar rat. Xenobiotica the fate of foreign compounds in biological systems, 15 (12). pp. 1061-1068.

[img] PDF
Download (56kB)

Abstract

1. Animals dosed orally with nitrite (1.5 × 10−3 mol/kg) and nonyl dimethylbenzylammonium bromide (2.9 × 10−4 mol/kg) exhibit liver damage within two hours; cetyl trimethylammonium bromide plus nitrite was not significantly hepatotoxic. 2. Both nonyl dimethylbenzyl ammonium bromide and cetyl trimethylammonium bromide were demethylated by rat-liver microsomal preparations; substrate concentrations of 1 mM or more were inhibitory. 3. Bile from rats given i.p. doses of cetyl trimethylammonium bromide, nonyl dimethylbenzylammonium bromide or dodecyl dimethylbenzylammonium bromide contains only metabolites, no unchanged compounds were detected.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Depositing User: Mrs Patricia Nwokealisi
Date Deposited: 23 Mar 2017 11:18
Last Modified: 23 Mar 2017 11:18
URI: http://eprints.covenantuniversity.edu.ng/id/eprint/8011

Actions (login required)

View Item View Item